Genesis 25:21 (KJV)
“And Isaac intreated the LORD for his wife, because she was barren: and the LORD was intreated of him, and Rebekah his wife conceived.”
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Context
Genesis 25 — surrounding verses
These are the sons of Ishmael, and these are their names, by their towns, and by their castles; twelve princes according to their nations.
17And these are the years of the life of Ishmael, an hundred and thirty and seven years: and he gave up the ghost and died; and was gathered unto his people.
18And they dwelt from Havilah unto Shur, that is before Egypt, as thou goest toward Assyria: and he died in the presence of all his brethren.
19And these are the generations of Isaac, Abraham's son: Abraham begat Isaac:
20And Isaac was forty years old when he took Rebekah to wife, the daughter of Bethuel the Syrian of Padanaram, the sister to Laban the Syrian.
And Isaac intreated the LORD for his wife, because she was barren: and the LORD was intreated of him, and Rebekah his wife conceived.
And the children struggled together within her; and she said, If it be so, why am I thus? And she went to enquire of the LORD.
23And the LORD said unto her, Two nations are in thy womb, and two manner of people shall be separated from thy bowels; and the one people shall be stronger than the other people; and the elder shall serve the younger.
24And when her days to be delivered were fulfilled, behold, there were twins in her womb.
25And the first came out red, all over like an hairy garment; and they called his name Esau.
26And after that came his brother out, and his hand took hold on Esau's heel; and his name was called Jacob: and Isaac was threescore years old when she bare them.